Endocrine Abstracts

Background: Pseudohypoparathyroidism (PHP) is a heterogeneous group of disorders characterized by hypocalcemia, hyperphosphatemia, increased serum concentration of parathyroid hormone (PTH) and insensitivity to the biological activity of PTH.Case report: We present the case of a 38-year-old man admitted to the Neurology Clinic in November 2007 for a witnessed grand mal seizure that resolved without intervention. Patient had a history of mental retardatio...

Introduction: The diagnostical and therapeutical management of GH-secreting pituitary adenomas has been modified in many aspects in the last decade, and the guidelines also have been considerably changed.Objective: To evaluate the management of acromegaly applied in an endocrinological clinical unit from Romania, and the efficiency of different therapeutical schemes.Materials and methods: 23 patients with acromegaly, treated and fo...

Thyroid-associated ophtalmopathy (TAO) is an organ-specific autoimmune process that is strongly associated with thyroid dysfunction. Patients with TAO may present eyelid retraction, proptosis, chemosis, periorbital oedema and altered ocular motility with significant functional and cosmetic consequences. There is the possibility of coexistence of two or more autoimmune diseases affecting the eye due to the cross-reactivity to common antigens from the eye muscles.<p class="a...

Objective: The latest studies on Graves’ ophthalmopathy (GO) emphasize the importance of the orbital adipose tissue and fibroblasts in the pathogenesis of the disease by secreting proinflammatory cytokines. In vitro, these cytokines were proved to have a major role in the maintenance and progress of inflammation in the orbit. The aim of this study was to investigate serum cytokine levels in patients with GO.Materials and methods: Serum interl...

Gonadotroph adenomas represent 40–50% of pituitary macroadenomas. Only a small subset of these tumors secrete sufficient hormone to elevate serum gonadotropin levels (functioning gonadotroph tumors).We are presenting the case of a 30-year-old male patient (E.R) having a characteristic symptomatology for the pituitary macroadenoma: headaches, impaired visual acuity and reduced visual field (based on ophthalmological examination). MRI (with gadolinium...